The desktop version of Trilium supports all three main operating systems:

- Windows
  - Windows 11 is officially supported.
  - Windows on ARM is also supported
- Linux:
  - Most modern distributions are supported, including NixOS.
  - ARM is supported in `aarch64` (no ARM v7 support).
- macOS
  - Minimum supported operating system: macOS Monterey
  - Both Intel and Apple Silicon devices are supported.